A subtype of liposarcoma, is a malignant tumor that arises in fat cells in deep soft tissue.
Myxoid liposarcomas occur most commonly in the lower extremity, particularly the thigh.
Liposarcomas originate from primitive mesenchymal cells rather than from mature fat cells.
At histologic analysis, they can be classified as well-differentiated, myxoid, pleomorphic, or round cell
abnormalities occur in myxoid liposarcoma, depending on:
- the amount of fat and myxoid material
- the degree of cellularity and vascularity
- the presence of necrosis.
- Most myxoid liposarcomas have lacy or linear, amorphous foci of fat.
A myxoid liposarcoma that contains abundant water can mimic a cystic lesion, producing diagnostic confusion. Myxoid liposarcomas must be differentiated from cystic lesions because the former can be limb threatening.
- varies with the histologic subtype.
- The well-differentiated variant is considered a low-grade malignancy
- the pleomorphic and round cell types are regarded as highly malignant tumors with a tendency toward local recurrence and metastasis.
Mi-Sook Sung, Heong S. Kang, Jin S. Suh, Jung H. Lee, Jeong M. Park, Jee Y. Kim, and Hae G. Lee. 2000. Mxoid Liposarcoma: Appearance at MR imaging with hisotlogic correlation. Radiographics. 20: 1007-1019.
Localized intracranial space occupying lesions.
- Tumors usually grow as a spherical mass or diffuse and infiltrate tissue
- occur from the compression and infiltration of tissue
- increased intracranial pressure
- cerebral edema
- seizure activity
- focal neurologic signs
- altered pituitary function
Effects of Neoplasm depend on the region of the brain occupied by the tumor:
Primary tumors: originate from cells and structures within the brain
Secondary (metastatic) tumors: develop from structures outside the brain
- occur in 20-40% of all patients with cancer
- brain tumors rarely metastasize outside the CNS
- metastasis origin
- lower GI tract
Glial and Meningeal tumors: linked to ionizing radiation exposure
- in adults – higher incidence in the fifth, sixth and seventh decades
- higher incidence in men than women
- Adult brain tumors originate most often originate from glial cells (forming the supportive structures of the spinal cord and CNS)
MRI of Brain tumor:
These tumors produce high levels of the hormone gastrin.
These tumors cause a hypersecretion of gastric acid that prodices peptic ulcers as a result of a non-beta cell tumor of the pancreatic islets.
- Abdominal pain
- Ulcers in the stomach and small bowel
- Hematemesis (Vomiting blood), rare
Tumor lysis syndrome (TLS) is a group of metabolic complications that can occur after treatment of cancer. TLS is caused by the fast breakdown of certain types of cancer cells. TLS can cause kidney failure and the need for dialysis treatment.
|Impairment of mental ability, and loss of consciousness
|Shortness of breath
|High Potassium levels (lab test)
|High Uric acid levels (lab test)
|Low calcium levels (lab test)
- hyperuricemia due to deoxyribonucleic acid (DNA) breakdown
- hyperkalemia because of cytosol breakdown
- hyperphosphatemia because of protein breakdown
- hypocalcemia secondary to the hyperphosphatemia.
As phoshate levels increase, serum calcium decreases.
These derangements can result in acute renal failure secondary to urate nephropathy, xanthine nephropathy, and the altered calcium phosphate blood levels.
Diagram of resultant acute renal failure:
Cardiac dysrhythmias can occur secondary to hyperkalemia and hypocalcemia
- Symptoms such as cramps can occur as a result of the increased blood calceum levles (hypocalcemia)
Sudden death may occur as a resultfrom hyperkalemia (increased blood potassium levels) or hypocalcemia (increased blood calceum levels).
Lymphomation. 2004. Tumor Lysis Syndrome. Retrieved Aug. 21, 2009 from http://www.lymphomation.org/side-effect-tumor-lysis.htm