rare neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs.
- muscle rigidity
- autonomic instability
- cognitive changes eg. delirium
- associated with elevated creatine phosphokinase (CPK)
A mneumonic used to remember the features of NMS is FEVER.
- F – Fever
- E – Encephalopathy
- V – Vitals unstable
- E – Elevated enzymes – CPK
- R – Rigidity of muscles
- symptom management
- removal from neuroleptic agent