Neuroleptic Malignant Syndrome (NMS)

rare neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs.


  1. muscle rigidity
  2. fever
  3. agitation
  4. autonomic instability
  5. cognitive changes eg. delirium
  6. associated with elevated creatine phosphokinase (CPK)

A mneumonic used to remember the features of NMS is FEVER.

  • F – Fever
  • E – Encephalopathy
  • V – Vitals unstable
  • E – Elevated enzymes – CPK
  • R – Rigidity of muscles


  • symptom management
  • removal from neuroleptic agent

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