Human herpesvirus 6 was the sixth herpesvirus discovered.
Isolated in 1986 during attempts to find novel viruses in patients with lymphoproliferative diseases
HHV-6 is now recognized as a T-lymohotrophic virus with high affinity for CD4 lymphocytes.
HHV-6 has two variants, A and B.
- HHV-6B causes the childhood illness roseola infantum, characterized by abrupt high fever and mild sore throat and rash.
- HHV-6A has been isolated mainly in immunocompromised hosts, characterized by manifestation as a mononucleosislike illness with fever, lymphadenopathy, and hepatitis or encephalitis, with negative test results for CMV or Epstein-Barr virus (EBV).
- Kikuchi lymphadenitis
- Drug-induced hypersensitivity syndrome3
- Systemic lupus erythematosus
- Chronic fatigue syndrome
- Guillain-Barré syndrome
- HHV-6 infection is the most common cause of febrile seizures in childhood (age 6-24 mo).
- Encephalitis may develop in children with HHV-6 infection.
- HHV-6 has a possible role in CNS infections and demyelinating conditions.
- HHV-6 infection may increase the severity of CMV infection in immunocompromised and transplant populations.
- HHV-6 has a possible role in lymphoproliferative syndromes.
- HHV-6 infection induces bone marrow suppression, respiratory failure, graft versus host disease, and encephalitis in patients undergoing hematopoietic stem cell or solid-organ transplantation.
Miele, Peter, S, Salvaggio, Michelle, R and Smith, Margo, A. 2010. Humanherpes Virus Type 6. Retrieved February, 2, 2010 from http://emedicine.medscape.com/article/219019-overview.