Myxoid Liposarcoma

A subtype of liposarcoma,  is a malignant tumor that arises in fat cells in deep soft tissue.

Myxoid liposarcomas occur most commonly in the lower extremity, particularly the thigh.

Liposarcomas originate from primitive mesenchymal cells rather than from mature fat cells.

At histologic analysis, they can be classified as well-differentiated, myxoid, pleomorphic, or round cell

abnormalities occur in myxoid liposarcoma, depending on:

  • the amount of fat and myxoid material
  • the degree of cellularity and vascularity
  • the presence of necrosis.
  • Most myxoid liposarcomas have lacy or linear, amorphous foci of fat.


  • MRI
  • CT

A myxoid liposarcoma that contains abundant water can mimic a cystic lesion, producing diagnostic confusion. Myxoid liposarcomas must be differentiated from cystic lesions because the former can be limb threatening.


  • varies with the histologic subtype.
  • The well-differentiated variant is considered a low-grade malignancy
  • the pleomorphic and round cell types are regarded as highly malignant tumors with a tendency toward local recurrence and metastasis.

Mi-Sook Sung, Heong S. Kang, Jin S. Suh, Jung H. Lee, Jeong M. Park, Jee Y. Kim, and Hae G. Lee. 2000. Mxoid Liposarcoma: Appearance at MR imaging with hisotlogic correlation. Radiographics. 20: 1007-1019.


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