Inflammatory Bowel Disease

 

Two chronic disorders:


1.Crohn`s disease
2.Ulcerative Colitis

Etiology:

Genetic susceptibility (no gene yet identified): Intolerance of normal gut flora by the body`s immune system.
Immune response is unregulated.

  1. Ulcerative Colitis
  • Chronic inflammation of the colon that produces ulcers in its lining
  • region of affected gut is continuous

 2. Crohn`s Disease

  • A chronic form of inflammatory bowel disease that usually affects the lower small intestine (called the ileum) or the colon
  • skip lesions in small and large intestine

 

Differentiating Characteristics of Crohn`s Disease and Ulcerative Colitis

Characteristics Crohn`s Disease Ulcerative Colitis
Type of inflammation Granulomatous Ulcerative and exudative:
Level of involvement submucosa mucosa
Area of involvement Ileum, colon Rectum and left colon
Extent of Involvement skip lesions in small and large intestine region of affected gut is continuous
Diarrhea common common
Rectal bleeding rare common
Fistuals common rare
Stricture common rare
Perianal abscesses Common Rare
Development of cancer Uncommon Relatively Common

 

Martin, Glenn and Porth, Carol, Mattson. 2009. Pathophysiology Concepts of Altered Health States. 8th ed. Lippincott Williams and Wilkins. Philadelphia

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