Meningitis and Encephalitis Comparision

 

Viral Meningitis Bacterial Meningitis Encephalitis
  1. Herpes Simplex
  2. Other
1. Haemopholis influenza – <5yrs2. Steptococcus pneumonia – adults3. Nesseria meningitis – youth
  1. Herpes Simplex
  2. Arboroviuses
  • Self resolution typical
  • HSV aggressive
  • Microbes replicate
  • toxins enter CSF
  • pus in subarachnoid space increases intracranial pressure
  • inflammation
  • purulent CSF
  • Localized necrosis and hemorrhage
  • edema
  • increased intracranial pressure
  • neural cell body death
  • neural fiber death
  • unpredictable progression
Normal glucose

Increased proteins

Lymphocytes

Low glucose

Increased proteins

Neutrophils

Normal glucose

Increased proteins

Lymphocytes

  • Headache
  • fever
  • nuchal rigidity
  • emesis
  • nausea
  • Headache
  • fever
  • nuchal rigidity
  • emesis
  • nausea
  • Neural disturbances: stupor, coma, lethargy, seizures

  • Headache
  • fever
  • nuchal rigidity
  • emesis
  • nausea
Antivirals for herpes simplex

other viruses – typical self resolution

Antibiotics

Steroids

Antivirals for herpes simplex

Arbovirus – typical self resolution in 2wks

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