|Feature||Multiple Sclerosis||Amyloid Lateral Sclerosis|
|Disease||Affects motor and sensory neurons||Affects motor neurons/ Sensory and cognition not affected|
|Incidence||Higher in women||Higher in men|
|Genetics||Mutation in the MHC portions of chromosomes on the HLA regions of the genes||Mutation of the SOD1 gene on chromosome 21|
|Pathophysiology||Neural demylination and Death of oligodenrocytes producing myelin||Superoxide dismutase gene that neutralizes harmful free radicals is mutated|
Signs and Symptoms
|Depends on the region and extent of neural demylination.
Paresthesia (burning, tingling sensation)
decreased muscle strength and coordination
bowel and bladder dysfunction
fascication (muscle twitch)
|Diagnostics||MRI for plaques.
Assay for presence of protein in CSF