Multiple Sclerosis and Amyloid Lateral Sclerosis Comparison

 

Feature Multiple Sclerosis Amyloid Lateral Sclerosis
Disease Affects motor and sensory neurons Affects motor neurons/ Sensory and cognition not affected
Incidence Higher in women Higher in men
Genetics Mutation in the MHC portions of chromosomes on the HLA regions of the genes Mutation of the SOD1 gene on chromosome 21
Pathophysiology Neural demylination and Death of oligodenrocytes producing myelin Superoxide dismutase gene that neutralizes harmful free radicals is mutated
Manifestations

Signs and Symptoms

Depends on the region and extent of neural demylination.

Paresthesia (burning, tingling sensation)

fatigue

decreased muscle strength and coordination

gait affected

visual impairment

bowel and bladder dysfunction

Weakness

fascication (muscle twitch)

muscle atrophy

dysphagia

dysarthria

Diagnostics MRI for plaques.

Assay for presence of protein in CSF

indiciative of:

  1. compromised blood brain barrier
  2. autoimmune damage occurance
  3. inflammatory processes

 

electromyography

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