Conn Syndrome (Primary aldosteronism or primary hyperaldosteronism)

 

  • aldosterone hypersecreation by adrenal glands
  • most commonly affecting those in the 30-50 yr age group
  • greater prevalence in women

Aldosterone:

Etiology

  1. cortical adenoma
  2. idiopathic cortical hyperplasia
  3. renal tumor – increase renin secetion

Manifestation

  • HTN due to Na2+ and H2O retention
  • hypokalemia (potassium is excreted by the kidneys as more Na2+ is retained)
  • alkalosis (high [aldosterone] causes H+ ion secretion)

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