The Coombs’ test determines the presence of erythrocyte specific antibodies (those that may bind to your red blood cells). The Coombs’ test is used to indicate the presence of autoimmune diseases such as Autoimmune Hemolytic Anemia. This disease is a result of the body’s own immune cells (immunoglobulins, Ig) being specific for and targeting its own red blood cells. This causes their premature destruction and removal from the blood stream. Anemia results.
FRAGKIADAKIS N, GIANNADAKI E, KYRIAKOU D, MANOUSOS O. N, POTAMIANOS S, and ROUSSOMOUSTAKAKI M.1997. Autoimmune hemolytic anemia and positive Coombs test associated with ulcerative colitis.
The American journal of gastroenterology. 92 (10) 1872-1874.