A disorder in which abnormal spleen activity causes the spleen to prematurely destroys blood cells that circulate in the blood. The spleen is responsible for destroying old red blood cells, that is red blood cells that have been in circulation for about 100-120 days.



1) primary hyperslpenism: an abnormality of the spleen itself

2) secondary hypersplenism: diseases of the blood cells, causing the spleen to remove infected or defective cells from the blood prematurely.


  • malaria
  • polycythemia vera
  • sickle cell anemia (condition of abnormal sickle cell shaped red blood cell formation)
  • spherocytosis (an abnormal condition of spherical red blood cells formation)

Health and Medical Topics. 2008. Hypersplenism. Retrived July 8, 2009 from http://www.faqs.org/health/topics/46/Hypersplenism.html


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