Tetralogy of Fallot (TOF) is a congenital (present at birth) heart defect which is classically understood to involve four anatomical abnormalities.
4 characteristic abnormalities:
- pulmonary stenosis
- ventricular septal defect
- malposition of the aorta over both ventricles
- hypertrophy of the right ventricle
- cyanosis at birth (blueish tinge of skin and mucus membranes indicative of inadequate oxygenation of tissues)
- Surgical repair of affected areas of the heart
- Complications include arrhythmias (a primary cause of late morbidity) and sudden cardia death
- Holter electrocarography has increased the detection of these post surgical arrhythmias, allowing for antiarrhythmic treatments.
M.Gatzoulis, S.Balaji, S.Webber, S.Siu, J.Hokanson, C.Poile, M.Rosenthal, M.Nakazawa, J.Moller, P.Gillette. 2000. Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study. The Lancet. 356: (9234) 975-981.