Reye’s syndrome

Reye’s syndrome is a disease characterized by:

  1. vomiting
  2. encephalopathy (disease of the brain)
  3. mental impairment
  4. personality changes
  5. deterioration of consciousness
  6. irritability, delirium and coma may accompany mental deterioration
  7. fatty degeneration of the liver

The disease usually presents after infection with varicella or influenza virus. Studies have demonstrated a strong epidemiologic association between the ingestion of aspirin during antecedent varicella or influenza-like illnesses and the subsequent development of Reye’s syndrome. The vast majority of cases present in children.

Diagnosis:

metabolic tests for:

  • hyperammonemia
  • elevated levels of alanine aminotransferase
  • aspartate aminotransferase

distinguishing test:

  • an electron micrograph
  • ultrastructural changes in liver tissue
  • specifically the proliferation of smooth endoplasmic reticulum and peroxisomes 
  • the presence of enlarged and pleomorphic mitochondria with loss of dense granules

Prognosis:

  • Reye’s syndrome is potentially fatal
  • The recovery of adults with the syndrome is generally complete, with liver and brain function returning to normal within two weeks of the illness
  • In children, mild to severe permanent brain damage is possible, especially in infants

Belay,

Ermias D., Bresee,Joseph S., Holman, Robert C, Khan, Ali S., Shahriari, Abtin, and Schonberger, Lawrence B. 1999. Reye’s Syndrome in the United States from 1981 through 1997. New England Journal of Medicine. 340 (18) :1377-1382.

 

 

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: