Locked in state syndrome (LIS)

Locked in state syndrome is a condition in which a patient is aware and awake, but cannot move or communicate due to complete paralysis of nearly all voluntary muscles in the body. Brain

It is the result of a brain stem lesion, injury in which the ventral part of the pons is damaged. This damage often occurs as the result of trauma or vascular conditions such as stroke.brain stem respiratory physiology

The condition has been described as “the closest thing to being buried alive”. In French, the common term is “maladie de l’emmuré vivant”, literally translated as walled-in alive disease; in German it is sometimes called “Eingeschlossensein”.

Locked-in syndrome is also known as

  • cerebromedullospinal disconnection
  • de-efferented state
  • pseudocoma
  • ventral pontine syndrome.

del Rosario Domiacutenguez-Morales, Mariacutea, Javier Peacuterez-Santamariacutea, Franciscoc, Leoacuten-Carrioacuten, Joseacute,  van Eeckhout, Philippe. 2002. Survey: The locked-in syndrome: a syndrome looking for a therapy. Brain Injury. 16 (7) 571 – 582.


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